Peptide recognition by T and B cells in rheumatoid arthritis

In this episode, Jane Buckner discusses how citrullinated tenascin-C is an autoantigen that is targeted by autoreactive CD4+ T cells and autoantibodies in patients with rheumatoid arthritis.
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Immunology of the rheumatoid joint

Rheumatoid arthritis is an inflammatory disease that mainly affects the joints in which the body’s immune system attacks its own tissues. This animation produced by Nature Reviews Immunology and Nature Reviews Rheumatology guides us through the immune pathways involved in the disease, from the first signs of self-reactive immune cells to joint damage and other symptoms, and highlights opportunities for new treatments.

Nature Reviews Immunology (http://www.nature.com/nri) and Nature Reviews Rheumatology (http://www.nature.com/nrrheum) have full responsibility for all editorial content. This content is editorially independent of sponsors.